Date of Award

8-2024

Document Type

Dissertation

Degree Name

Doctor of Medical Science (DMSc)

Abstract

Generalized anxiety disorder (GAD) is a common disorder affecting approximately 4% to 7% of US adults. The Diagnostic and Statistical Manual of Mental Disorders defines GAD as persistent and excessive worrying about various aspects of life that occurs most days for at least six months. This anxiety is excessive in both its intensity and its scope, impacting various aspects of life and causing significant impairment in daily functioning. Due to its high prevalence, there is a need for effective and safe treatments. Current guidelines for treatment of GAD recommend either monotherapy or combination therapy using pharmacological and/or psychosocial modalities. Pharmacological treatments include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), benzodiazepines, anticonvulsants, and antipsychotics. Options for psychosocial treatment include relaxation techniques, physical exercise, yoga, acupuncture, biofeedback, nondirective psychotherapy, and cognitive-behavioral therapy. Despite the wide variety of therapies available for GAD, many of those suffering from the disease continue to have poorly managed symptoms. Additionally, pharmacological interventions can be poorly tolerated due to side effects or other drug interactions.

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