Date of Award


Document Type


Degree Name

Doctor of Medical Science (DMSc)


Department of Physician Assistant Medicine

First Advisor

Kristy Asbell, PA-C

Second Advisor

Michelle Rhea, PA-C


Purpose A growing amount of research has constituted lipoprotein(a) as an independent risk factor for cardiovascular disease. The main objective of this review is to summarize the current guidelines for testing and managing Lp(a) and provide guidance to clinicians on how to practically utilize Lp(a) with what is known today. Methods: EBSCO, PubMed, and Ovid were searched for this review. Search terms included lipoprotein(a), clinical practice, guidelines, screening, and cardiovascular disease. Sources within ten years were obtained to cover recent material. Results: The current literature on the association between Lp(a) and CVD outcomes and up-to-date guidelines on testing and management suggest that Lp(a) is actionable for clinical use today. Conclusion: Lp(a) is strongly defined as a CVD risk factor. Therefore, several professional organizations continue shifting guidelines on treatment and management to aid clinicians today despite the lack of Lp(a) targeted therapeutics