Date of Award

Winter 12-15-2022

Document Type


Degree Name

Doctor of Medical Science (DMSc)


Department of Physician Assistant Medicine

First Advisor

Justin M. Gambini, DMSc, PA-C, DFAAPA


Background: Cannabis is widely used among males and females of reproductive age. A growing body of research suggests the endocannabinoid system is negatively impacted by the use of cannabis affecting many factors required for fertility. Objective: This article aims to evaluate existing literature on trends seen in patients undergoing artificial reproductive therapy (ART) and the effects cannabis has on fertility outcomes, including conception. Methods: This is a systematic review searching PubMed, MEDLINE, and Academic Search Premier databases through August 2022 using keywords derived from three defined concepts. Articles were then evaluated for relevance and included if meeting criteria. Results: Three studies meeting criteria were included in this article review. All three studies were retrospective or prospective studies conducted on human populations of single clinics.

Conclusion: Present studies aiming to evaluate any demonstrable detrimental effects of cannabis consumption on ART outcomes have been universally limited by small sample size, narrow geographical reach, self-reporting, and other confounding variables. Further studies are needed with larger sample sizes to more meaningfully assess the effects of cannabis on fertility and ART outcomes.